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PI3K Inhibition (delta, gamma) Program


We are interested in requests related to PI3K Inhibition. The phosphoinositide 3-kinase (PI3K) signaling pathway is a key regulator in cancer proliferation (rapid increase or spread) and metastasis (development of secondary growths away from a primary site of cancer). The PI3K pathway includes four Class I isoforms: alpha, beta, delta and gamma (α, β, δ, and γ). The four isoforms play unique roles in the survival of different tumor types and in the creation of supportive tumor microenvironments.



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